diff --git a/security/py-cryptodome/Makefile b/security/py-cryptodome/Makefile
index 4df966e413e..622bac67a51 100644
--- a/security/py-cryptodome/Makefile
+++ b/security/py-cryptodome/Makefile
@@ -1,9 +1,8 @@
 COMMENT=	self-contained cryptographic library for Python
 
-MODPY_DISTV=	3.21.0
+MODPY_DISTV=	3.22.0
 DISTNAME=	pycryptodome-${MODPY_DISTV}
 PKGNAME=	py-${DISTNAME:S/py//}
-REVISION=	1
 
 CATEGORIES=	security
 
@@ -15,7 +14,6 @@ MAINTAINER=	Stuart Henderson <stu.ports@spacehopper.org>
 PERMIT_PACKAGE=	Yes
 
 MODULES=	lang/python
-
 MODPY_PI=	Yes
 MODPY_PYBUILD=	setuptools
 
diff --git a/security/py-cryptodome/distinfo b/security/py-cryptodome/distinfo
index 6108c7ab4ab..b0ddcfd02ca 100644
--- a/security/py-cryptodome/distinfo
+++ b/security/py-cryptodome/distinfo
@@ -1,2 +1,2 @@
-SHA256 (pycryptodome-3.21.0.tar.gz) = 93h+DUab2udjuHYXTPLmwPe+eYCK8msdqW8aZLz0cpc=
-SIZE (pycryptodome-3.21.0.tar.gz) = 4818071
+SHA256 (pycryptodome-3.22.0.tar.gz) = /Xq1aLOte3fJCNfD9+Fn7FqPA1xk/3TxDUek7dBD1yM=
+SIZE (pycryptodome-3.22.0.tar.gz) = 4917300
diff --git a/security/py-cryptodome/pkg/PLIST b/security/py-cryptodome/pkg/PLIST
index 73b76b11339..dfc884a7198 100644
--- a/security/py-cryptodome/pkg/PLIST
+++ b/security/py-cryptodome/pkg/PLIST
@@ -321,6 +321,7 @@ lib/python${MODPY_VERSION}/site-packages/Crypto/Math/${MODPY_PYCACHE}__init__.${
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/DH.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/DH.pyi
+lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/HPKE.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/KDF.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/KDF.pyi
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/SecretSharing.py
@@ -330,6 +331,8 @@ lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/__init__.pyi
 ${MODPY_COMMENT}lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}/
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}DH.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}DH.${MODPY_PYC_MAGIC_TAG}pyc
+lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}HPKE.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
+lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}HPKE.${MODPY_PYC_MAGIC_TAG}pyc
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}KDF.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}KDF.${MODPY_PYC_MAGIC_TAG}pyc
 lib/python${MODPY_VERSION}/site-packages/Crypto/Protocol/${MODPY_PYCACHE}SecretSharing.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
@@ -582,6 +585,8 @@ lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/__init__.py
 ${MODPY_COMMENT}lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}/
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}__init__.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}__init__.${MODPY_PYC_MAGIC_TAG}pyc
+lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_HPKE.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
+lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_HPKE.${MODPY_PYC_MAGIC_TAG}pyc
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_KDF.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_KDF.${MODPY_PYC_MAGIC_TAG}pyc
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_SecretSharing.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
@@ -590,6 +595,7 @@ lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACH
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_ecdh.${MODPY_PYC_MAGIC_TAG}pyc
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_rfc1751.${MODPY_PYC_MAGIC_TAG}${MODPY_PYOEXTENSION}
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/${MODPY_PYCACHE}test_rfc1751.${MODPY_PYC_MAGIC_TAG}pyc
+lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/test_HPKE.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/test_KDF.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/test_SecretSharing.py
 lib/python${MODPY_VERSION}/site-packages/Crypto/SelfTest/Protocol/test_ecdh.py